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44. Aerobic Oxidative Coupling of 2‑Aminonaphthalenes byHomogenous Nonheme Iron Catalysts

Vlada Vershinin, Li-noy Feruz, Hagit Forkosh, Lina Kertzman, Anna Libman, Jordi Burés* and Doron Pappo*

ACS Catal. 2024, 14, 8261−8269.


43.  Dynamic Thermodynamic Resolution of Racemic 1,1′-Binaphthyl-2,2′-diol (BINOL)

Omer Shaashua, Dennis Pollok, Alina Dyadyuk, Alexander I. Shames, Siegfried R. Waldvogel*, and Doron Pappo*

Org. Lett. 2024, 26, 10, 2129–2134.

TOC Mar5.tif

42.  Multicopper Clusters Enable Oxidative Phenol Macrocyclization (OxPM) of Peptides

Anna Libman, Mor Ben-Lulu, Eden Gaster, Ratnadeep Bera, ALexander I. Shames, Omer Shaashua, Vlada Vershinin, Yuri Torubaev and Doron Pappo

J. Am. Chem. Soc. 2023, 145 (38), 21002-21011.

Published first in ChemRxiv, preprint 2023

41.  A Chiral Iron Disulfonate Catalyst for the Enantioselective Synthesis of 2-Amino-2′-hydroxy-1,1′-binaphthyls (NOBINs)

Alina Dyadyuk, Vlada Vershinin, Hadas Shalit, Hen Shalev, Nagnath Yadav More, and Doron Pappo
J. Am. Chem. Soc. 2022, 144 (8), 3676-3684.


40.  Iron-Catalyzed Oxidative Cross-Coupling of Phenols and Tyrosine Derivatives with 3-Alkyloxindoles

Tomer Mintz, Nagnath Yadav More, Eden Gaster and Doron Pappo
 J. Org. Chem. 
2021, 86, 24, 18164–18178.

TOC - oxindole-phenol JOC 2021.tiff

39.  Mechanistic Insights into the FeCl3-Catalyzed Oxidative Cross-Coupling of Phenols with 2-Aminonaphthalenes

Vlada Vershinin, Hagit Forkosh, Mor Ben-Lulu, Anna Libman and Doron Pappo
 J. Org. Chem. 
2020, 86,1, 79-90.

TOC Vlada JOC 2020.png

38.  Flat corannulene: when a transition state becomes a stable molecule

Ephrath Solel, Doron Pappo, Ofer Reany, Tom Mejuch, Renana Gershoni-Poranne, Mark Botoshansky, Amnon Stanger and Ehud Keinan Chem. Sci. 2020, 11, 13015-13025.

DOI: 10.1039/d0sc04566g

TOC figure- flat corannulene.tiff

37.  Dual‐Acting Small‐Molecule Inhibitors Targeting Mycobacterial DNA Replication

Meenakshi Singh, Stefan Ilic, Benjamin Tam, Yesmin Ben-Ishay, Dror Sherf, Doron Pappo and Barak Akabayov
 Chem. Eur. J. 
2020, 26, 10849-10860

36.  M[TPP]Cl (M = Fe or Mn)-Catalyzed Oxidative Amination of Phenols by Primary and Secondary Anilines

Vlada Vershinin and Doron Pappo Org. Lett. 2020, 22, 5, 1941-1946


35.  Synthesis of Biaryl‐Bridged Cyclic Peptides via Catalytic Oxidative Cross‐Coupling Reactions

Mor Ben-Lulu, Eden Gaster, Anna Libman, and Doron Pappo Angew. Chem. Int. Ed.  2020, 59 (12), 4835-4839

DOI: 10.1002/anie.201913305

[Highlighted in SYNFACTS 2020, 16(03), 0351]

34.  Cobalt(II)[salen] Catalyzed Selective Aerobic Oxidative Cross‑Coupling between Electron-Rich Phenols and 2-Naphthols

Hagai Reiss, Hadas Shalit, Vlada Vershinin, Nagnath Yadav More, Hagit Forckosha, and Doron Pappo J. Org. Chem. 2019, 84, 12, 7950-7960.

DOI: 10.1021/acs.joc.9b00822


33.  Selective Oxidative Phenol Coupling by Iron Catalysis

Hadas Shalit,† Alina Dyadyuk,† Doron Pappo J. Org. Chem.  2019, 1677-1686.

DOI: 10.1021/acs.joc.8b03084

 †These authors contributed equally to this work.

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32.  Stereoselective Synthesis of Optically Pure 2-Amino-2'-Hydroxy-1,1'-Binaphthyls [NOBINs]

Hagit Forkosh,† Vlada Vershinin,† Hagai Reiss, Doron Pappo Org. Lett. 2018, 20, 8, 2459-2463

DOI: 10.1021/acs.orglett.8b00800

 †These authors contributed equally to this work.

NOBINs Org Lett 2018-1.gif
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31. Organic Synthesis: From Glorious Past to Brilliant Future 

Ehud Keinan, Doron Pappo Israel. J. Chem. 2018, 58, 7 – 10.

DOI: 10.1002/ijch.201800012

29. meso-Tetraphenylporphyrin Iron Chloride Catalyzed Selective Oxidative Cross-Coupling of Phenols

Hadas Shalit,† Anna Libman,† Doron Pappo J. Am. Chem. Soc. 2017, 139 (38), 13404–13413.

DOI: 10.1021/jacs.7b05898

†These authors contributed equally to this work.


30. Cu(OTf)2 Catalyzed Pummerer Coupling of beta-Ketosulfoxide

Regev Parnes, Hagai Reiss and Doron Pappo J. Org. Chem. 2018, 83 (2), 723–732.  

DOI: 10.1021/acs.joc.7b02708

TOC - Pummerer.gif

28. Iron Phosphate Catalyzed Asymmetric Cross-Dehydrogenative Coupling of 2-Napthols with beta-Ketoesters

Sachin Narute, Doron Pappo  Org. Lett. 2017, 19 (11), 2917–2920.



27. Selective Aerobic Oxidation of Methylarenes to Benzaldehydes Catalyzed by NHPI and Co(OAc)2 in HFIP 

Eden Gaster, Sebastian Kozuch, Doron Pappo  Angew. Chem. Int. Ed. 2017,  56, 5912-5915.

DOI: 10.1002/anie.201702511

Selected as a Very Important Paper (VIP)

Eden TOC.png

26. Iron-Catalyzed Selective Oxidative Arylation of Phenols and Biphenols

Vlada Vershinin, Alina Dyadyuk, Doron Pappo Tetrahedron 2017, 73(26), 3660-3668.

DOI: 10.1016/j.tet.2017.03.094

[Tetrahedron Young Investigator Prize Special Issue in honor of Professor Ang Li]

TOC Tetrahedron 2017.jpg

25. Enantioselective Oxidative Homo- and Cross-Coupling of 2-Naphthols Catalyzed by Chiral Iron Phosphate Complexes

Sachin Narute, Regev Parnes, F. Dean Toste, Doron Pappo J. Am. Chem. Soc. 2016, 138 (50), 16553–16560. 

DOI: 10.1021/jacs.6b11198 

[Highlighted in SYNFACTS 2017, 273]

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24. Direct Synthesis of Polyaryls by Consecutive Oxidative Cross-Coupling of Phenols with Arenes​

Alina Dyadyuk, Kavitha Sudheendran, Yulia Vainer, Vlada Vershinin, Alexander I. Shames and Doron Pappo Org. Lett. 2016, 4324-4327. 

DOI: 10.1021/acs.orglett.6b02064​

polyarenes 1.JPG

23. A Synthetic and Predictive Approach to Unsymmetrical Biphenols by Iron-Catalyzed Chelated Radical-Anion Oxidative Coupling

Anna Libman, Hadas Shalit,† Yulia Vainer, Sachin Narute, Sebastian Kozuch and Doron Pappo J. Am. Chem. Soc. 2015, 11,453-11,460.

DOI: 10.1021/jacs.5b06494

 †These authors contributed equally to this work.

jacs 2015.png

22. Reductive Alkylation of Arenes by a Thiol-Based Multicomponent Reaction

Regev Parnes and Doron Pappo Org. Lett. 2015, 2924-2927.

DOI: 10.1021/acs.orglett.5b01142


21. Iron Catalyzed Oxidative C-C and C-O Coupling of Halophenols to α-substituted β-ketoesters

Almog Regev, Hadas Shalit and Doron Pappo SYNTHESIS 2015, 47(12), 1716-1725.

DOI: 10.1055/s-0034-1380360 

[Special issue: Iron in Organic Synthesis]  

Almog hadas.PNG

20. Significant Enhancement in Efficiency and Selectivity of Iron-Catalyzed Oxidative Cross-Coupling of Phenols by Fluoroalcohols

Eden Gaster,† Yulia Vainer,† Almog Regev, Sachin Narute, Kavitha Sudheendran, Aviya Werbeloff, Hadas Shalit and Doron Pappo Angew. Chem. Int. Ed. 2015, 54 (14), 4198-4202.

DOI: 10.1002/anie.201409694 

†These authors contributed equally to this work.


19. Thiol-Promoted Selective Addition of Ketones to Aldehydes

 Regev Parnes,† Sachin Narute† and Doron Pappo Org. Lett. 2014,  16 (22), 5922–5925. 

DOI: 10.1021/ol502937n

 †These authors contributed equally to this work.

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18. Multifarenes: New Modular Cavitands

Galit Parvari, Senthilmurugan Annamalai, Helena Chechik, Mark Botoshansky, Doron Pappo and Ehud Keinan Chem. Commun. 2014, 50, 2494-2497.

DOI: 10.1039/C3CC48284G 

[Highlighted in SYNFACTS 2014, 375]


17. Copper-Mediated Cross Coupling Reactions

Edited by G. Evano and N. Blanchard, WILEY, 2013.

Doron Pappo, Chapter 17: Natural Products and C-O Bond Forming Reactions: Copper Showed the Way.

DOI: 10.1002/9781118690659.ch17 


16. Iron-Catalyzed Oxidative Cross-Coupling of Phenols and Alkenes

Umesh A. Kshirsagar, Clil Regev, Regev Parnes and Doron Pappo Org. Lett.2013, 15 (12), 3174-3177.

DOI: 10.1021/ol401532a


15. Aerobic Iron-Based Cross-Dehydrogenative Coupling Enables Efficient Diversity-Oriented Synthesis of Coumestrol-Based Selective Estrogen Receptor Modulators

Umesh A. Kshirsagar,† Parnes, Regev,† Hagit Goldshtein, Rivka Ofir, Raz Zarivach, Doron Pappo Chem. Eur. J., 2013, 19 (40), 13575-13583. 

DOI: 10.1002/chem.201300389

 †These authors contributed equally to this work.


14. Ligand Controlled Iron-Catalyzed Coupling of a-Substituted β-Ketoesters with Phenols

 Regev Parnes, Umesh A. Kshirsagar, A. Werbeloff, Clil Regev, Doron Pappo Org. Lett., 2012,  14(13), 3324-3327. 

DOI: 10.1021/ol301297k

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13. Deca-heterosubstituted corannulenes

Alla Pogoreltsev, Ephrath Solel, Doron Pappo, Ehud Keinan Chem. Commun., 2012, 48, 5425-5427.

DOI: 10.1039/C2CC31801F


12. Corannulene Ethers via Ullmann Condensation

Renana Gershoni-Poranne, Doron Pappo, Ephrath Solel, Ehud Keinan Org. Lett., 2009, 11 (22), 5146-5149. 

DOI: 10.1021/ol902352k

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11. Diverse Functionalization of Corannulene: Easy Access to Pentagonal Superstructures

Doron Pappo, Tom Mejuch, Ofer Reany, Ephrath Solel, Ehud Keinan Org. Lett., 2009, 11 (5), 1063-1066.

DOI: 10.1021/ol8028127

doron 2009.gif

10. Cyclic Endiamino Peptides; A New Synthesis of Imidazopyrazines

Yael Kogon, Lee Goren, Doron Pappo, Amira Rudi, Yoel Kashman Eur. J. Org. Chem. 2009, 12, 1852-1854.

DOI: 10.1002/ejoc.200900008

9. Acyclic and Cyclic Thioenamine peptides; Solution and Solid phase Synthesis

Lee Goren, Doron Pappo, Israel Goldberg, Yoel Kashman, Tetrahedron Letters, 2009, 50, 1048-1050.

DOI: 10.1016/j.tetlet.2008.12.072  

8. A Chiral Pool Based Synthesis of Platensimycin

K.C. Nicolaou, Doron Pappo, K. Y. Tsang, Romelo Gibe, David Y.-K. Chen Angew. Chem. Int. Ed., 2008, 47(5), 944-946.

DOI: 10.1002/anie.200705080 

[Highlighted in SYNFACTS] 

7. Total Synthesis of Kinamycins C, F and J

K.C. Nicolaou, Hongming Li, Andrean L. Nold, Doron Pappo, Achim Lenzen, J. Am. Chem. Soc., 2007, 129(34), 10356-10357.

DOI: 10.1021/ja074297d


6. Recent Heterocyclic Compounds from Marine Invertebrates; Structure and Synthesis 

Yoel Kashman, Amira Rudi, Doron Pappo Pure Appl. Chem. 2007, 79(4), 491-505.



5. β-Turn Mimetic:  Synthesis of Cyclic Thioenamino Peptides

Doron Pappo and Yoel Kashman Org. Lett., 2006, 8 (6), 1177-1179.



4. Synthesis of Cyclic Endiamino Peptides 

Doron Pappo, Maida Vartanian, Stephan Lang, Yoel Kashman J. Am. Chem. Soc., 2005, 127 (21), 7682-7683.

DOI: 10.1021/ja050299r


3. Synthesis of 9-Substituted Tetrahydrodiazepinopurines: Studies Toward the Total Synthesis of Asmarines

Doron Pappo, Shiri Shimony, Yoel Kashman J. Org. Chem., 2005, 70, 199-206.

DOI: 10.1021/jo048622g



5. β-Turn Mimetic: Synthesis of Cyclic Thioenamino Peptides

Doron Pappo, Yoel Kashman Org. Lett., 2006, 8(6), 1177-1179.

DOI: 10.1021/ol060075t


2. Synthesis of 9-Substituted Tetrahydrodiazepinopurines- Asmarine A Analogues

 Doron Pappo, Yoel Kashman, Tetrahedron, 2003, 59, 6493-6501.

DOI: 10.1016/S0040-4020(03)01058-5


asmarines a analogues.PNG

1. A Synthetic Approach Toward the Synthesis of Asmarine Analogues

Doron Pappo, Amira Rudi, Yoel Kashman Tetrahedron Letters, 2001, 42, 5941-5943.

DOI: 10.1016/S0040-4039(01)01111-x


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